The study was recently published in the scientific journal Science, a collaboration between PharmaMar and the research laboratories of Kris White, Adolfo García-Sastre and Thomas Zwaka in the Department of Cell, Developmental and Regenerative Biology at the Icahn School of Medicine at Mount Sinai; Kevan Shokat and Nevan Krogan at the Institute for Quantitative Biosciences at UC Berkeley; and of Marco Vignuzzi at the Institut Pasteur in Paris.
In vitro testing is promising as they reveal that the drug developed by PharmaMar with Plitidepsin would have an antiviral efficacy against SARS-CoV-2 virus significantly higher than the only antiviral approved to date to treat COVID-19, Remdesivir. In addition, in two different animal models of coronavirus infection, viral loads in the lungs of those treated with coronavirus decreased by 99%. And although the trial is still in the so-called preclynic phases I and II, if the results are good in these early stages, the passage to phase III, where the efficacy of the drug is tested in humans.
Since last October, the Research Support in Applied Chemistry and Biotechnology (CQAB) at Universidad de Alcalá has been collaborating with PharmaMar with the aim of 'accelerating the production of the Plitidepsine molecule, through the synthesis of some fragments of the molecule', according to Professor Juan José Vaquero, Scientific Director of CQAB.
The Research Support Centre was designed and created by the UAH more than 20 years ago with the aim of promoting public-private collaboration through the development of projects, contracts and services in areas such as pharmacochemistry, bioanalytics, biotechnology, materials and, more recently, circular economy, and since its inception, has collaborated with more than 100 national and multinational companies and 30 public research centres.
Javier de la Mata, vice-chancellor of Research and Transfer at the UAH, stresses the importance of this collaboration, 'since it shows that both our researchers and the scientific-technical equipment of our University are up to this important development and evidence the quality of the University's research activity, both nationally and internationally.'